Phospholipase C and Protein Kinase C-β 2 Mediate Insulin-Like Growth Factor II-Dependent Sphingosine Kinase 1 Activation

We recently reported that IGF-II binding to the IGF-II/mannose-6-phosphate (M6P) receptor activates the ERK1/2 cascade by triggering sphingosine kinase 1 (SK1)-dependent transactivation of G protein-coupled sphingosine 1-phosphate (S1P) receptors. Here, we investigated the mechanism of IGF-II/M6P re...

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Detalhes bibliográficos
Main Authors: El-Shewy, Hesham M., Abdel-Samie, Souzan A., Al Qalam, Abdelmohsen M., Lee, Mi-Hye, Kitatani, Kazuyuki, Anelli, Viviana, Jaffa, Ayad A., Obeid, Lina M., Luttrell, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2011
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231827/
https://ncbi.nlm.nih.gov/pubmed/22016563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-0101
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