Duplicated zebrafish insulin-like growth factor binding protein-5 genes with split functional domains: evidence for evolutionarily conserved IGF binding, nuclear localization, and transactivation activity

Insulin-like growth factor binding protein (IGFBP)-5 is a secreted protein that binds to IGF and modulates IGF actions. IGFBP-5 is also found in the nucleus of mammalian cells and has transactivation activity. The structural basis of this transactivation activity and its role in mediating IGF-indepe...

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Autores principales: Dai, Wei, Kamei, Hiroyasu, Zhao, Yang, Ding, Jun, Du, Zhou, Duan, Cunming
Formato: Artigo
Lenguaje:Inglês
Publicado: The Federation of American Societies for Experimental Biology 2010
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3231792/
https://ncbi.nlm.nih.gov/pubmed/20081093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-149435
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