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A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells

BACKGROUND: Bruton's tyrosine kinase (Btk) is essential for B cell development and function. Mutations of Btk elicit X-linked agammaglobulinemia in humans and X-linked immunodeficiency in the mouse. Btk has been proposed to participate in B cell antigen receptor-induced signaling events leading to a...

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Udgivet i:BMC Immunol
Principais autores: Tomlinson, Michael G, Woods, Douglas B, McMahon, Martin, Wahl, Matthew I, Witte, Owen N, Kurosaki, Tomohiro, Bolen, Joseph B, Johnston, James A
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2001
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC32313/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11410123/
https://ncbi.nlm.nih.govhttps://doi.org/10.1186/1471-2172-2-4
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