Biogenesis of the platelet receptor for fibrinogen: evidence for separate precursors for glycoproteins IIb and IIIa.

Congenital absence of platelet glycoproteins IIb and IIIa (GPIIb and GPIIIa) results in a severe bleeding disorder characterized by defective platelet aggregation and failure of fibrinogen to bind to platelets. GPIIb is a two-chain protein containing disulfide-linked alpha and beta subunits. GPIIb a...

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Publié dans:	Proc Natl Acad Sci U S A
Auteurs principaux:	Bray, P F, Rosa, J P, Lingappa, V R, Kan, Y W, McEver, R P, Shuman, M A
Format:	Artigo
Langue:	Inglês
Publié:	National Academy of Sciences 1986
Sujets:	Research Article
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC323100/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3006053/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.5.1480
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