Activation of LXR Increases Acetaminophen Clearance and Prevents Its Toxicity

Overdose of acetaminophen (APAP), the active ingredient of Tylenol, is the leading cause of drug-induced acute liver failure in the US. As such, it is necessary to develop novel strategies to prevent or manage APAP toxicity. In this report, we revealed a novel function of the liver X receptor (LXR)...

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Detalhes bibliográficos
Main Authors: Saini, Simrat P.S., Zhang, Bin, Niu, Yongdong, Jiang, Mengxi, Gao, Jie, Zhai, Yonggong, Lee, Jung Hoon, Uppal, Hirdesh, Tian, Hui, Tortorici, Michael A., Poloyac, Samuel M., Qin, Wenxin, Venkataramanan, Raman, Xie, Wen
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230770/
https://ncbi.nlm.nih.gov/pubmed/21898498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24646
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