Activation of LXR Increases Acetaminophen Clearance and Prevents Its Toxicity

Overdose of acetaminophen (APAP), the active ingredient of Tylenol, is the leading cause of drug-induced acute liver failure in the US. As such, it is necessary to develop novel strategies to prevent or manage APAP toxicity. In this report, we revealed a novel function of the liver X receptor (LXR)...

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Библиографические подробности
Главные авторы: Saini, Simrat P.S., Zhang, Bin, Niu, Yongdong, Jiang, Mengxi, Gao, Jie, Zhai, Yonggong, Lee, Jung Hoon, Uppal, Hirdesh, Tian, Hui, Tortorici, Michael A., Poloyac, Samuel M., Qin, Wenxin, Venkataramanan, Raman, Xie, Wen
Формат: Artigo
Язык:Inglês
Опубликовано: 2011
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230770/
https://ncbi.nlm.nih.gov/pubmed/21898498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24646
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