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Disparate degrees of hypervariable loop flexibility control T cell receptor cross-reactivity, specificity, and binding mechanism
αβ T cell receptors recognize multiple antigenic peptides bound and presented by major histocompatibility complex molecules. TCR cross-reactivity has been attributed in part to flexibility of the complementarity-determining region loops, yet there have been limited direct studies of loop dynamics to...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3230710/ https://ncbi.nlm.nih.gov/pubmed/22019736 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.006 |
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