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The Crystal Structure Analysis of Group B Streptococcus Sortase C1: A Model for the ‘lid’ Movement upon Substrate Binding

A unique feature of the class-C-type sortases, enzymes essential for Gram-positive pilus biogenesis, is the presence of a flexible ‘lid’ anchored in the active site. However, the mechanistic details of the ‘lid’ displacement, suggested to be a critical prelude for enzyme catalysis, are not yet known...

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Detalhes bibliográficos
Main Authors: Khare, Baldeep, Fu, Zheng-Qing, Huang, I-Hsiu, Ton-That, Hung, Narayana, V. L Sthanam
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230703/
https://ncbi.nlm.nih.gov/pubmed/22033482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.10.017
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