Human Oxidation-Specific Antibodies Reduce Foam Cell Formation and Atherosclerosis Progression

OBJECTIVES: We sought to assess the in vivo importance of scavenger receptor (SR)-mediated uptake of oxidized low density lipoprotein (OxLDL) in atherogenesis and test the efficacy of human antibody IK17-Fab or IK17 single chain Fv fragment (IK17-scFv), which lack immunological properties of intact...

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Detalhes bibliográficos
Main Authors: Tsimikas, Sotirios, Miyanohara, Atsushi, Hartvigsen, Karsten, Merki, Esther, Shaw, Peter X., Chou, Meng-Yun, Pattison, Jennifer, Torzewski, Michael, Sollors, Janina, Friedmann, Theodore, Lai, N. Chin, Hammond, H. Kirk, Getz, Godfrey S., Reardon, Catherine A., Li, Andrew C., Banka, Carole L., Witztum, Joseph L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230644/
https://ncbi.nlm.nih.gov/pubmed/21982317
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jacc.2011.07.017
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