miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA

MicroRNAs (miRNAs) are ∼22 nt non-coding RNAs that typically bind to the 3′ UTR of target mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression. Here, we report that miRNAs can also regulate gene expression by targeting non-coding antisense transcripts in human cells...

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Autori principali: Hansen, Thomas B, Wiklund, Erik D, Bramsen, Jesper B, Villadsen, Sune B, Statham, Aaron L, Clark, Susan J, Kjems, Jørgen
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230379/
https://ncbi.nlm.nih.gov/pubmed/21964070
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.359
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