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miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA
MicroRNAs (miRNAs) are ∼22 nt non-coding RNAs that typically bind to the 3′ UTR of target mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression. Here, we report that miRNAs can also regulate gene expression by targeting non-coding antisense transcripts in human cells...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3230379/ https://ncbi.nlm.nih.gov/pubmed/21964070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.359 |
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