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miRNA-dependent gene silencing involving Ago2-mediated cleavage of a circular antisense RNA
MicroRNAs (miRNAs) are ∼22 nt non-coding RNAs that typically bind to the 3′ UTR of target mRNAs in the cytoplasm, resulting in mRNA destabilization and translational repression. Here, we report that miRNAs can also regulate gene expression by targeting non-coding antisense transcripts in human cells...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Nature Publishing Group
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3230379/ https://ncbi.nlm.nih.gov/pubmed/21964070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.359 |
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