Inhibitory GH Receptor Extracellular Domain Monoclonal Antibodies: Three-Dimensional Epitope Mapping

GH receptor (GHR) mediates the anabolic and metabolic effects of GH. We previously characterized a monoclonal antibody (anti-GHR(ext-mAb)) that reacts with subdomain 2 of the rabbit GHR extracellular domain (ECD) and is a conformation-specific inhibitor of GH signaling in cells bearing rabbit or hum...

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Autores principales: Jiang, Jing, Wan, Yu, Wang, Xiangdong, Xu, Jie, Harris, Jonathan M., Lobie, Peter E., Zhang, Yu, Zinn, Kurt R., Waters, Michael J., Frank, Stuart J.
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2011
Materias:
Growth Hormone-Somatostatin-GRH
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3230063/
https://ncbi.nlm.nih.gov/pubmed/21990310
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1336
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