Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects.

We report that residues Lys-16 and Asp-119 play critical roles in the guanine nucleotide binding and, consequently, the biological function of the Ha-ras-encoded protein (Ha). Substitution of an asparagine residue for Lys-16 reduces the affinity of Ha for GDP and GTP by a factor of 100 but does not...

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Détails bibliographiques
Auteurs principaux: Sigal, I S, Gibbs, J B, D'Alonzo, J S, Temeles, G L, Wolanski, B S, Socher, S H, Scolnick, E M
Format: Artigo
Langue:Inglês
Publié: 1986
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC322988/
https://ncbi.nlm.nih.gov/pubmed/3513168
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