Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities.

The activity of leukotriene A4 (LTA4) synthase in crude human leukocyte homogenates was found to have a similar requirement for Ca2+ and ATP as had been noted previously for 5-lipoxygenase activity. Purification of the 5-lipoxygenase using ammonium sulfate fractionation, AcA 44 gel-filtration chroma...

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Vydáno v:	Proc Natl Acad Sci U S A
Hlavní autoři:	Rouzer, C A, Matsumoto, T, Samuelsson, B
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	National Academy of Sciences 1986
Témata:	Research Article
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC322969/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3006030/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.83.4.857
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