Significance of p53-binding protein 1 nuclear foci in uterine cervical lesions: endogenous DNA double strand breaks and genomic instability during carcinogenesis

AIMS: A defective DNA damage response can result in genomic instability (GIN) and lead to transformation to cancer. As p53-binding protein 1 (53BP1) localizes at the sites of DNA double strand breaks (DSBs) and rapidly forms nuclear foci (NF), the presence of 53BP1 NF can be considered to be an indi...

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Detalhes bibliográficos
Main Authors: Matsuda, Katsuya, Miura, Shiro, Kurashige, Tomomi, Suzuki, Keiji, Kondo, Hisayoshi, Ihara, Makoto, Nakajima, Hisayoshi, Masuzaki, Hideaki, Nakashima, Masahiro
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2011
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229684/
https://ncbi.nlm.nih.gov/pubmed/22034884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2559.2011.03963.x
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