PAX8 promotes tumor cell growth by transcriptionally regulating E2F1 and stabilizing RB protein

The retinoblastoma protein (RB)–E2F1 pathway has a central role in regulating the cell cycle. Several PAX proteins (tissue-specific developmental regulators), including PAX8, interact with the RB protein, and thus regulate the cell cycle directly or indirectly. Here, we report that PAX8 expression i...

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Autori principali: Li, C G, Nyman, J E, Braithwaite, A W, Eccles, M R
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229668/
https://ncbi.nlm.nih.gov/pubmed/21602887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2011.190
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