A Novel Retinoblastoma Protein (RB) E3 Ubiquitin Ligase (NRBE3) Promotes RB Degradation and Is Transcriptionally Regulated by E2F1 Transcription Factor

Retinoblastoma protein (RB) plays critical roles in tumor suppression and is degraded through the proteasomal pathway. However, E3 ubiquitin ligases responsible for proteasome-mediated degradation of RB are largely unknown. Here we characterize a novel RB E3 ubiquitin ligase (NRBE3) that binds RB an...

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Bibliografiset tiedot
Julkaisussa:J Biol Chem
Päätekijät: Wang, Yingshuang, Zheng, Zongfang, Zhang, Jingyi, Wang, You, Kong, Ruirui, Liu, Jiangying, Zhang, Ying, Deng, Hongkui, Du, Xiaojuan, Ke, Yang
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Biochemistry and Molecular Biology 2015
Aiheet:
Cell Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4653678/
https://ncbi.nlm.nih.gov/pubmed/26442585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.655597
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