Molecular insights on the peripheral and intra-tumoral effects of systemic high dose rIL-2 (Aldesleukin) administration for the treatment of metastatic melanoma

PURPOSE: We have previously shown that within tumors, recombinant interleukin-2 (rIL-2, Aldesleukin) consistently activates tumor-associated macrophages and up-regulates interferon stimulated genes (ISGs) while inducing minimal migration, activation or proliferation of T-cells. These effects are ind...

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Hauptverfasser: Weiss, Geoffrey R., Grosh, William W., Chianese-Bullock, Kimberly A., Zhao, Yingdong, Liu, Hui, Slingluff, Craig L., Marincola, Francesco M, Wang, Ena
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229653/
https://ncbi.nlm.nih.gov/pubmed/21976537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1650
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