Molecular insights on the peripheral and intra-tumoral effects of systemic high dose rIL-2 (Aldesleukin) administration for the treatment of metastatic melanoma

PURPOSE: We have previously shown that within tumors, recombinant interleukin-2 (rIL-2, Aldesleukin) consistently activates tumor-associated macrophages and up-regulates interferon stimulated genes (ISGs) while inducing minimal migration, activation or proliferation of T-cells. These effects are ind...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Weiss, Geoffrey R., Grosh, William W., Chianese-Bullock, Kimberly A., Zhao, Yingdong, Liu, Hui, Slingluff, Craig L., Marincola, Francesco M, Wang, Ena
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229653/
https://ncbi.nlm.nih.gov/pubmed/21976537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-1650
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados