Nicotinamide Inhibits Alkylating Agent-Induced Apoptotic Neurodegeneration in the Developing Rat Brain

BACKGROUND: Exposure to the chemotherapeutic alkylating agent thiotepa during brain development leads to neurological complications arising from neurodegeneration and irreversible damage to the developing central nerve system (CNS). Administration of single dose of thiotepa in 7-d postnatal (P7) rat...

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Main Authors: Ullah, Najeeb, Lee, Hae Young, Naseer, Muhammad Imran, Ullah, Ikram, Suh, Joo Won, Kim, Myeong Ok
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2011
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229474/
https://ncbi.nlm.nih.gov/pubmed/22164206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027093
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