Depletion of Acyl-Coenzyme A-Binding Protein Affects Sphingolipid Synthesis and Causes Vesicle Accumulation and Membrane Defects in Saccharomyces cerevisiae

Deletion of the yeast gene ACB1 encoding Acb1p, the yeast homologue of the acyl-CoA-binding protein (ACBP), resulted in a slower growing phenotype that adapted into a faster growing phenotype with a frequency >1:10(5). A conditional knockout strain (Y700pGAL1-ACB1) with the ACB1 gene under contro...

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Main Authors: Gaigg, Barbara, Neergaard, Thomas B. F., Schneiter, Roger, Hansen, Jan Krogh, Færgeman, Nils J., Jensen, Niels A., Andersen, Jens R., Friis, Jørgen, Sandhoff, Roger, Schrøder, Henrik Daa, Knudsen, Jens
Formato: Artigo
Idioma:Inglês
Publicado: The American Society for Cell Biology 2001
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC32293/
https://ncbi.nlm.nih.gov/pubmed/11294913
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