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A new look at glutamate and ischemia: NMDA agonist improves long-term functional outcome in a rat model of stroke

Ischemic stroke triggers a massive, although transient, glutamate efflux and excessive activation of NMDA receptors (NMDARs), possibly leading to neuronal death. However, multiple clinical trials with NMDA antagonists failed to improve, or even worsened, stroke outcome. Recent findings of a persiste...

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Detalhes bibliográficos
Main Authors: Dhawan, Jasbeer, Benveniste, Helene, Luo, Zhongchi, Nawrocky, Marta, Smith, S David, Biegon, Anat
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3229223/
https://ncbi.nlm.nih.gov/pubmed/22140354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2217/fnl.11.55
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