Neonatal CD8 T-cell Hierarchy Is Distinct from Adults and Is Influenced by Intrinsic T cell Properties in Respiratory Syncytial Virus Infected Mice

Following respiratory syncytial virus infection of adult CB6F1 hybrid mice, a predictable CD8+ T cell epitope hierarchy is established with a strongly dominant response to a K(d)-restricted peptide (SYIGSINNI) from the M2 protein. The response to K(d)M2(82-90) is ∼5-fold higher than the response to...

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Detalhes bibliográficos
Main Authors: Ruckwardt, Tracy J., Malloy, Allison M. W., Gostick, Emma, Price, David A., Dash, Pradyot, McClaren, Jennifer L., Thomas, Paul G., Graham, Barney S.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228797/
https://ncbi.nlm.nih.gov/pubmed/22144888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1002377
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