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Insulin-Like Growth Factor I–Mediated Skeletal Muscle Hypertrophy Is Characterized by Increased mTOR-p70S6K Signaling without Increased Akt Phosphorylation

BACKGROUND: Insulin-like growth factor I (IGF-I) is an anabolic hormone that is known to induce skeletal muscle hypertrophy. However, the signaling pathways mediating IGF-I's hypertrophic effect in vivo are unknown. METHOD: The phosphorylation of 46 proteins was investigated by Kinetworks prote...

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Bibliografiske detaljer
Main Authors: Song, Yao-Hua, Godard, Michael, Li, Yangxin, Richmond, Scott R., Rosenthal, Nadia, Delafontaine, Patrick
Format: Artigo
Sprog:Inglês
Udgivet: 2005
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228637/
https://ncbi.nlm.nih.gov/pubmed/15921033
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