Crystal structure of the Lassa virus nucleoprotein–RNA complex reveals a gating mechanism for RNA binding

Arenaviruses cause disease in industrialized and developing nations alike. Among them, the hemorrhagic fever virus Lassa is responsible for ∼300,000–500,000 infections/y in Western Africa. The arenavirus nucleoprotein (NP) forms the protein scaffold of the genomic ribonucleoprotein complexes and is...

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Main Authors: Hastie, Kathryn M., Liu, Tong, Li, Sheng, King, Liam B., Ngo, Nhi, Zandonatti, Michelle A., Woods, Virgil L., de la Torre, Juan Carlos, Saphire, Erica Ollmann
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2011
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228486/
https://ncbi.nlm.nih.gov/pubmed/22084115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108515108
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