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Organ aging and susceptibility to cancer may be related to the geometry of the stem cell niche

Telomere loss at each cell replication limits the proliferative capacity of normal cells, including adult stem cells. Entering replicative senescence protects dividing cells from neoplastic transformation, but also contributes to aging of the tissue. Recent experiments have shown that intestinal mou...

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Detalhes bibliográficos
Autor principal: Blagoev, Krastan B.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228473/
https://ncbi.nlm.nih.gov/pubmed/22084067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106105108
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