Ectopic Matrix Metalloproteinase 9 Expression in Human Brain Tumor Cells Enhances Oncolytic HSV Vector Infection

Oncolytic HSV (oHSV) vectors have shown promise in the treatment of patients with recurrent brain tumors although few complete responses have accrued. Impediments to effective therapy include limited vector distribution on delivery, a consequence of injected virion particle trapping in the tumor ext...

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Autors principals: Hong, Chang-Sook, Fellows, Wendy, Niranjan, Ajay, Alber, Sean, Watkins, Simon, Cohen, Justus B., Glorioso, Joseph C., Grandi, Paola
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228315/
https://ncbi.nlm.nih.gov/pubmed/20463757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2010.66
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