Ectopic Matrix Metalloproteinase 9 Expression in Human Brain Tumor Cells Enhances Oncolytic HSV Vector Infection

Oncolytic HSV (oHSV) vectors have shown promise in the treatment of patients with recurrent brain tumors although few complete responses have accrued. Impediments to effective therapy include limited vector distribution on delivery, a consequence of injected virion particle trapping in the tumor ext...

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Main Authors: Hong, Chang-Sook, Fellows, Wendy, Niranjan, Ajay, Alber, Sean, Watkins, Simon, Cohen, Justus B., Glorioso, Joseph C., Grandi, Paola
Format: Artigo
Jezik:Inglês
Izdano: 2010
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3228315/
https://ncbi.nlm.nih.gov/pubmed/20463757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2010.66
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