Cyclophosphamide Dose Intensification May Circumvent Anthracycline Resistance of p53 Mutant Breast Cancers

The predictive value of p53 for the efficacy of front-line anthracycline-based chemotherapy regimens has been a matter of significant controversy. Anthracyclines are usually combined with widely different doses of alkylating agents, which may significantly modulate tumor response to these combinatio...

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Main Authors: Lehmann-Che, Jacqueline, André, Fabrice, Desmedt, Christine, Mazouni, Chafika, Giacchetti, Sylvie, Turpin, Elisabeth, Espié, Marc, Plassa, Louis-François, Marty, Michel, Bertheau, Philippe, Sotiriou, Christos, Piccart, Martine, Symmans, W. Fraser, Pusztai, Lajos, de Thé, Hugues
Format: Artigo
Sprog:Inglês
Udgivet: AlphaMed Press 2010
Fag:
Breast Cancer
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227956/
https://ncbi.nlm.nih.gov/pubmed/20228131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1634/theoncologist.2009-0243
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