O4-Methyl, -ethyl, or -isopropyl substituents on thymidine in poly(dA-dT) all lead to transitions upon replication.

In a previous paper, we reported that O4-methyl dTTP can be incorporated into poly(dA-dT) in place of thymidine without distortion of the helical structure, but on replication it could behave as deoxycytidine and misincorporate dGTP. Only weak interactions are possible for any O4-modified T X A pair...

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Hlavní autoři: Singer, B, Spengler, S J, Fraenkel-Conrat, H, Kuśmierek, J T
Médium: Artigo
Jazyk:Inglês
Vydáno: 1986
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC322784/
https://ncbi.nlm.nih.gov/pubmed/3455756
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