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Inhibition of Rho Kinase Regulates Specification of Early Differentiation Events in P19 Embryonal Carcinoma Stem Cells

BACKGROUND: The Rho kinase pathway plays a key role in many early cell/tissue determination events that take place in embryogenesis. Rho and its downstream effector Rho kinase (ROCK) play pivotal roles in cell migration, apoptosis (membrane blebbing), cell proliferation/cell cycle, cell-cell adhesio...

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Detalhes bibliográficos
Main Authors: Krawetz, Roman J., Taiani, Jaymi, Greene, Alexis, Kelly, Gregory M., Rancourt, Derrick E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227584/
https://ncbi.nlm.nih.gov/pubmed/22140430
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026484
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