Replicative senescence of mesenchymal stem cells causes DNA-methylation changes which correlate with repressive histone marks

Cells in culture undergo replicative senescence. In this study, we analyzed functional, genetic and epigenetic sequels of long-term culture in human mesenchymal stem cells (MSC). Already within early passages the fibroblastoid colonyforming unit (CFU-f) frequency and the differentiation potential of...

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Main Authors: Schellenberg, Anne, Lin, Qiong, Schüler, Herdit, Koch, Carmen M., Joussen, Sylvia, Denecke, Bernd, Walenda, Gudrun, Pallua, Norbert, Suschek, Christoph V., Zenke, Martin, Wagner, Wolfgang
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2011
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227452/
https://ncbi.nlm.nih.gov/pubmed/22025769
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