(−)-Gossypol, a Natural BH3 Mimetic, Suppresses the Growth of Human Prostate Cancer Xenografts via Modulating VEGF Signaling-Mediated Angiogenesis

(−)-Gossypol, a natural BH3-mimetic and small-molecule Bcl-2 inhibitor, shows promise in ongoing phase II clinical trials for human cancers. However, whether (−)-gossypol plays functional roles in tumor angiogenesis has not been directly elucidated yet. In this study, we demonstrated that (−)-gossyp...

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Detalhes bibliográficos
Main Authors: Pang, Xiufeng, Wu, Yuanyuan, Wu, Yougen, Lu, Binbin, Chen, Jing, Wang, Jieqiong, Yi, Zhengfang, Qu, Weijing, Liu, Mingyao
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227412/
https://ncbi.nlm.nih.gov/pubmed/21372225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-10-0936
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