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Delineation of key regulatory elements identifies points of vulnerability in the mitogen-activated signaling network
Drug development efforts against cancer are often hampered by the complex properties of signaling networks. Here we combined the results of an RNAi screen targeting the cellular signaling machinery, with graph theoretical analysis to extract the core modules that process both mitogenic and oncogenic...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Cold Spring Harbor Laboratory Press
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3227097/ https://ncbi.nlm.nih.gov/pubmed/21865350 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.116145.110 |
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