Delineation of key regulatory elements identifies points of vulnerability in the mitogen-activated signaling network

Drug development efforts against cancer are often hampered by the complex properties of signaling networks. Here we combined the results of an RNAi screen targeting the cellular signaling machinery, with graph theoretical analysis to extract the core modules that process both mitogenic and oncogenic...

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Main Authors: Jailkhani, Noor, Ravichandran, Srikanth, Hegde, Shubhada R., Siddiqui, Zaved, Mande, Shekhar C., Rao, Kanury V.S.
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2011
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227097/
https://ncbi.nlm.nih.gov/pubmed/21865350
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.116145.110
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