A CRHR1 Haplotype Moderates the Effect of Adverse Childhood Experiences on Lifetime Risk of Major Depressive Episode in African-American Women

BACKGROUND: Adverse childhood experiences (ACEs) increase the risk for adult depression and substance dependence, possibly mediated by the corticotropin-releasing hormone type 1 receptor (CRHR1). In some studies, a three-SNP “T-A-T” haplotype in CRHR1, which encodes CRHR1, exerted a protective moder...

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Bibliografiske detaljer
Main Authors: Kranzler, Henry R., Feinn, Richard, Nelson, Elliot C., Covault, Jonathan, Anton, Raymond F., Farrer, Lindsay, Gelernter, Joel
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3227028/
https://ncbi.nlm.nih.gov/pubmed/21998007
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajmg.b.31243
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