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Adiponectin inhibits leptin signaling via multiple mechanisms to exert protective effects against hepatic fibrosis
Adiponectin is protective against hepatic fibrosis, while leptin promotes fibrosis. In hepatic stellate cells (HSCs), leptin signals via a Janus Kinase 2/Signal Transducers and Activators of Transcription 3 (Jak2/Stat3) pathway, producing effects that enhance extracellular matrix deposition. Suppres...
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| Главные авторы: | , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3226855/ https://ncbi.nlm.nih.gov/pubmed/21846328 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20102148 |
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