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Fast and Accurate Approximation to Significance Tests in Genome-Wide Association Studies
Genome-wide association studies commonly involve simultaneous tests of millions of single nucleotide polymorphisms (SNP) for disease association. The SNPs in nearby genomic regions, however, are often highly correlated due to linkage disequilibrium (LD, a genetic term for correlation). Simple Bonfer...
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| Hauptverfasser: | , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3226809/ https://ncbi.nlm.nih.gov/pubmed/22140288 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1198/jasa.2011.ap10657 |
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