Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3′,4′-Hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells

5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone (5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels of sweet orange. In this research, we report the first investigation of the neurotrophic effects and mechanism of 5-OH-HxMF in PC12 pheochrom...

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Hlavní autoři: Lai, Hui-Chi, Wu, Ming-Jiuan, Chen, Pei-Yi, Sheu, Ting-Ting, Chiu, Szu-Ping, Lin, Meng-Han, Ho, Chi-Tang, Yen, Jui-Hung
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226691/
https://ncbi.nlm.nih.gov/pubmed/22140566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028280
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