Neurotrophic Effect of Citrus 5-Hydroxy-3,6,7,8,3′,4′-Hexamethoxyflavone: Promotion of Neurite Outgrowth via cAMP/PKA/CREB Pathway in PC12 Cells

5-Hydroxy-3,6,7,8,3′,4′-hexamethoxyflavone (5-OH-HxMF), a hydroxylated polymethoxyflavone, is found exclusively in the Citrus genus, particularly in the peels of sweet orange. In this research, we report the first investigation of the neurotrophic effects and mechanism of 5-OH-HxMF in PC12 pheochrom...

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Detalhes bibliográficos
Main Authors: Lai, Hui-Chi, Wu, Ming-Jiuan, Chen, Pei-Yi, Sheu, Ting-Ting, Chiu, Szu-Ping, Lin, Meng-Han, Ho, Chi-Tang, Yen, Jui-Hung
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3226691/
https://ncbi.nlm.nih.gov/pubmed/22140566
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028280
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