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Congenital Cataract Causing Mutants of αA-Crystallin/sHSP Form Aggregates and Aggresomes Degraded through Ubiquitin-Proteasome Pathway
BACKGROUND: Mutations of human αA-crystallin cause congenital cataract by protein aggregation. How mutations of αA-crystallin cause disease pathogenesis through protein aggregation is not well understood. To better understand the cellular events leading to protein aggregation, we transfected catarac...
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| Formato: | Artigo |
| Idioma: | Inglês |
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Public Library of Science
2011
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| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3226672/ https://ncbi.nlm.nih.gov/pubmed/22140512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0028085 |
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