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Transmission of prions within the gut and toward the central nervous system
The prion protein is a glycoprotein characterized by a folded α-helical structure that, under pathological conditions, misfolds and aggregates into its infectious isoform as β-sheet rich amyloidic deposits. The accumulation of the abnormal protein is responsible for a group of progressive and fatal...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Landes Bioscience
2011
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3226038/ https://ncbi.nlm.nih.gov/pubmed/21814041 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/pri.5.3.16328 |
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