Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice

The majority of human pancreatic cancers have activating mutations in the KRAS proto-oncogene. These mutations result in increased activity of the NF-κB pathway and the subsequent constitutive production of proinflammatory cytokines. Here, we show that inhibitor of κB kinase 2 (Ikk2), a component of...

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Bibliographic Details
Main Authors: Maniati, Eleni, Bossard, Maud, Cook, Natalie, Candido, Juliana B., Emami-Shahri, Nia, Nedospasov, Sergei A., Balkwill, Frances R., Tuveson, David A., Hagemann, Thorsten
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225987/
https://ncbi.nlm.nih.gov/pubmed/22056382
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45797
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