Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter

Leptin is a master regulator of energy homeostasis. Its expression, prevalently localized in adipocytes, is positively related to adipose mass. Epigenetics is emerging as an important contributor to the changes in gene expression undergone by adipose tissue during obesity. We herein investigated the...

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Bibliographic Details
Main Authors: Marchi, Matilde, Lisi, Simonetta, Curcio, Michele, Barbuti, Serena, Piaggi, Paolo, Ceccarini, Giovanni, Nannipieri, Monica, Anselmino, Marco, Di Salvo, Claudio, Vitti, Paolo, Pinchera, Aldo, Santini, Ferruccio, Maffei, Margherita
Format: Artigo
Language:Inglês
Published: Landes Bioscience 2011
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225841/
https://ncbi.nlm.nih.gov/pubmed/21931275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.6.10.16600
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