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Human leptin tissue distribution, but not weight loss-dependent change in expression, is associated with methylation of its promoter

Leptin is a master regulator of energy homeostasis. Its expression, prevalently localized in adipocytes, is positively related to adipose mass. Epigenetics is emerging as an important contributor to the changes in gene expression undergone by adipose tissue during obesity. We herein investigated the...

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Autori principali: Marchi, Matilde, Lisi, Simonetta, Curcio, Michele, Barbuti, Serena, Piaggi, Paolo, Ceccarini, Giovanni, Nannipieri, Monica, Anselmino, Marco, Di Salvo, Claudio, Vitti, Paolo, Pinchera, Aldo, Santini, Ferruccio, Maffei, Margherita
Natura: Artigo
Lingua:Inglês
Pubblicazione: Landes Bioscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225841/
https://ncbi.nlm.nih.gov/pubmed/21931275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/epi.6.10.16600
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