The Association of PNPLA3 Variants with Liver Enzymes in Childhood Obesity Is Driven by the Interaction with Abdominal Fat

BACKGROUND AND AIMS: A polymorphism in adiponutrin/patatin-like phospholipase-3 gene (PNPLA3), rs738409 C->G, encoding for the I148M variant, is the strongest genetic determinant of liver fat and ALT levels in adulthood and childhood obesity. Aims of this study were i) to analyse in a large group...

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Main Authors: Miraglia del Giudice, Emanuele, Grandone, Anna, Cirillo, Grazia, Santoro, Nicola, Amato, Alessandra, Brienza, Carmine, Savarese, Piera, Marzuillo, Pierluigi, Perrone, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225386/
https://ncbi.nlm.nih.gov/pubmed/22140488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027933
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