Alterations in the Interleukin-1/Interleukin-1 Receptor Antagonist Balance Modulate Cardiac Remodeling following Myocardial Infarction in the Mouse

BACKGROUND: Healing after acute myocardial infarction (AMI) is characterized by an intense inflammatory response and increased Interleukin-1 (IL-1) tissue activity. Genetically engineered mice lacking the IL-1 receptor (IL-1R1-/-, not responsive to IL-1) or the IL-1 receptor antagonist (IL-1Ra, enha...

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Bibliographic Details
Main Authors: Abbate, Antonio, Salloum, Fadi N., Van Tassell, Benjamin W., Vecile, Elena, Toldo, Stefano, Seropian, Ignacio, Mezzaroma, Eleonora, Dobrina, Aldo
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225370/
https://ncbi.nlm.nih.gov/pubmed/22140485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027923
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