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Effects of allopurinol and oxipurinol on purine synthesis in cultured human cells

In the present study we have examined the effects of allopurinol and oxipurinol on the de novo synthesis of purines in cultured human fibroblasts. Allopurinol inhibits de novo purine synthesis in the absence of xanthine oxidase. Inhibition at lower concentrations of the drug requires the presence of...

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Detalhes bibliográficos
Main Authors: Kelley, William N., Wyngaarden, James B.
Formato: Artigo
Idioma:Inglês
Publicado em: 1970
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC322509/
https://ncbi.nlm.nih.gov/pubmed/5415686
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