Potassium Channel Activity and Glutamate Uptake are Impaired in Astrocytes of Seizure Susceptible DBA/2 Mice

PURPOSE: KCNJ10 encodes subunits of inward rectifying potassium (Kir) channel Kir4.1 found predominantly in glial cells within the brain. Genetic inactivation of these channels in glia impairs extracellular K(+) and glutamate clearance and produces a seizure phenotype. In both mice and humans, polym...

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Auteurs principaux: Inyushin, Mikhail, Kucheryavykh, Lilia Y., Kucheryavykh, Yuriy V., Nichols, Colin G., Buono, Russell J., Ferraro, Thomas N., Skatchkov, Serguei N., Eaton, Misty J.
Format: Artigo
Langue:Inglês
Publié: 2010
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3225007/
https://ncbi.nlm.nih.gov/pubmed/20831751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1528-1167.2010.02592.x
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