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Anti-tumor effects of a human VEGFR-2-based DNA vaccine in mouse models
BACKGROUND: Vascular endothelial growth factor (VEGF) and its receptor, VEGFR-2 (Flk-1/KDR), play a key role in tumor angiogenesis. Blocking the VEGF-VEGFR-2 pathway may inhibit tumor growth. Here, we used human VEGFR-2 as a model antigen to explore the feasibility of immunotherapy with a plasmid DN...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
BioMed Central
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3224891/ https://ncbi.nlm.nih.gov/pubmed/19545394 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-0556-7-10 |
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