Nitric oxide protects the heart from ischemia-induced apoptosis and mitochondrial damage via protein kinase G mediated blockage of permeability transition and cytochrome c release

BACKGROUND: Heart ischemia can rapidly induce apoptosis and mitochondrial dysfunction via mitochondrial permeability transition-induced cytochrome c release. We tested whether nitric oxide (NO) can block this damage in isolated rat heart, and, if so, by what mechanisms. METHODS: Hearts were perfused...

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Main Authors: Borutaite, Vilmante, Morkuniene, Ramune, Arandarcikaite, Odeta, Jekabsone, Aiste, Barauskaite, Jurgita, Brown, Guy C
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2009
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224577/
https://ncbi.nlm.nih.gov/pubmed/19671187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1423-0127-16-70
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