Evaluating the role of connexin43 in congenital heart disease: Screening for mutations in patients with outflow tract anomalies and the analysis of knock-in mouse models

BACKGROUND: GJA1 gene encodes a gap junction protein known as connexin 43 (Cx43). Cx43 is abundantly expressed in the ventricular myocardium and in cardiac neural crest cells. Cx43 is proposed to play an important role in human congenital heart disease, as GJA1 knock-out mice die neonatally from out...

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Detalhes bibliográficos
Main Authors: Huang, Guo-Ying, Xie, Li-Jian, Linask, Kaari L., Zhang, Chen, Zhao, Xiao-Qing, Yang, Yi, Zhou, Guo-Min, Wu, Ying-Jie, Marquez-Rosado, Lucrecia, McElhinney, Doff B., Goldmuntz, Elizabeth, Liu, Chengyu, Lampe, Paul D., Chatterjee, Bishwanath, Lo, Cecilia W.
Formato: Artigo
Idioma:Inglês
Publicado em: Medknow Publications Pvt Ltd 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3224440/
https://ncbi.nlm.nih.gov/pubmed/22135478
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4103/0975-3583.89804
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