Ciliogenesis is regulated by a huntingtin-HAP1-PCM1 pathway and is altered in Huntington disease

Huntington disease (HD) is a devastating autosomal-dominant neurodegenerative disorder. It is caused by expansion of a CAG repeat in the first exon of the huntingtin (HTT) gene that encodes a mutant HTT protein with a polyglutamine (polyQ) expansion at the amino terminus. Here, we demonstrate that W...

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Главные авторы: Keryer, Guy, Pineda, Jose R., Liot, Géraldine, Kim, Jinho, Dietrich, Paula, Benstaali, Caroline, Smith, Karen, Cordelières, Fabrice P., Spassky, Nathalie, Ferrante, Robert J., Dragatsis, Ioannis, Saudou, Frédéric
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Clinical Investigation 2011
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223861/
https://ncbi.nlm.nih.gov/pubmed/21985783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI57552
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