Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

Cisplatin is a widely used cancer therapy drug that unfortunately has major side effects in normal tissues, notably nephrotoxicity in kidneys. Despite intensive research, the mechanism of cisplatin-induced nephrotoxicity remains unclear, and renoprotective approaches during cisplatin-based chemother...

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Autors principals: Pabla, Navjotsingh, Dong, Guie, Jiang, Man, Huang, Shuang, Kumar, M. Vijay, Messing, Robert O., Dong, Zheng
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical Investigation 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3223835/
https://ncbi.nlm.nih.gov/pubmed/21633170
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45586
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